-TRN-000632 is a potent allosteric inhibitor of BCR-ABL in development for the treatment of CML-, -Terns is eligible to receive an upfront fee and milestone payments of up to $68 million plus royalties on future product sales-, -Preclinical and clinical studies evaluating TRN-000632 to be conducted in the partnership-. Based in China and the United States, the company is advancing a pipeline of drug candidates for the treatment of non-alcoholic steatohepatitis (NASH), primary biliary cholangitis (PBC), and cancer, across multiple modalities. Inhibition of SSAO may provide a therapeutic benefit for patients with NASH and other chronic fibrotic liver diseases by reducing oxidative stress and the recruitment of inflammatory cells into the liver. -Results from single and multiple ascending dose cohorts demonstrate TERN-201 is generally safe and well tolerated and results in potent and sustained inhibition of plasma SSAO activity-. Margaret Robinson About Terns Pharmaceuticals Terns Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on developing best-in-class … Terns Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company that is focused on the discovery and development of medicines for chronic liver disease and cancer. Inhibition of SSAO is believed to have therapeutic benefit for the treatment of NAFLD, NASH and other chronic fibrotic liver diseases. The level of surface SSAO is upregulated in the vasculature of inflamed tissues, and soluble SSAO levels are elevated in patients with NASH. Secondary endpoints included pharmacokinetics (PK) and pharmacodynamic (PD) biomarker assessments of SSAO target engagement. Zhou Zhou Welcome. About TERN-501 and Thyroid Hormone Receptor Beta (THR-β)THR-β is a nuclear hormone receptor that is highly expressed in the liver and plays a central role in lipid metabolism, regulation of blood cholesterol and triglyceride levels, and prevention of steatosis (excess fat buildup in the liver). For more information, visit www.ternspharma.com, Investor Relations Contact: Founded in 1995, Hansoh has fully integrated research and development, manufacturing, and commercial capabilities, supporting leading positions in oncology, central nervous system (CNS) disorders, infectious diseases, gastrointestinal disorders, diabetes, and autoimmune diseases, among others in China. Mean percent of baseline SSAO activity following once daily administration of placebo or TERN-201: About Semicarbazide-Sensitive Amine Oxidase (SSAO) Inhibition and TERN-201, SSAO, also known as VAP-1 (Vascular Adhesion Protein-1), is a dual-function amine oxidase which increases oxidative stress through the generation of H2O2 and promotes recruitment of white blood cells in the liver, which results in increased oxidative stress, inflammation and hepatic fibrosis. "Overall, these data suggest TERN-201 is an industry-leading SSAO inhibitor with the potential to be a promising new therapy for NASH and other inflammatory diseases,” said Erin Quirk, M.D., President and Chief Medical Officer of Terns. Certain MAOs could be associated with potential drug-drug interactions in the NASH patient population. About Terns Pharmaceuticals. Global rates of NAFLD and NASH are increasing rapidly, in tandem with rising rates of obesity. Each dose level studied showed potent target engagement and achieved near complete inhibition of plasma SSAO activity that was maintained up to one week after single dose or repeat dose administrations of TERN-201. Mark Vignola FOSTER CITY, Calif. & SHANGHAI--(BUSINESS WIRE)--Terns Pharmaceuticals, Inc., a global biopharmaceutical company focused on discovering and developing innovative therapies to treat liver disease and cancer, and Hansoh Pharmaceutical Group Company Limited (“Hansoh Pharma”; 3692:HK), a leading biopharmaceutical company in Asia, today announced a collaboration and license agreement for the development and commercialization of TRN-000632, an investigational small molecule allosteric inhibitor of BCR-ABL for the treatment of chronic myeloid leukemia (CML), in Greater China. For more information, visit www.ternspharma.com and www.ternspharma.com.cn, About Hansoh Pharmaceutical Group Company Limited. Terns announced in July 2020 positive Phase 1 clinical data for its highly-selective SSAO inhibitor, TERN-201, demonstrating potent and sustained target engagement. Sophia Dong Terns Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on developing best-in-class single-agent and combination therapies to treat liver …
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