Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma, Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia, Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation, Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells, Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma, Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers, Heterotrimeric Gi proteins link hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration, Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways, The patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex, Teratogen-mediated inhibition of target tissue response to Shh signaling, Inhibition of Hedgehog signaling by direct binding of cyclopamine to smoothened, Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists, GDC-0449-a potent inhibitor of the Hedgehog pathway, Discovery of NVP-LDE225, a potent and selective smoothened antagonist, Abstract 4504: PF-04449913, a small molecule inhibitor of Hedgehog signaling, is effective in inhibiting tumor growth in preclinical models, Abstract 2823: TAK-441, a novel investigational small molecule hedgehog pathway inhibitor for use in cancer therapy, Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors, Inhibition of the Hedgehog pathway in advanced basal-cell carcinoma, CO14. Conception and design: R. McMillan, W. Matsui, Writing, review, and/or revision of the manuscript: R. McMillan, W. Matsui. A, in the absence of HH ligand, PTCH1 inhibits SMO allowing the GLI processing complex containing SUFU to generate transcriptional repressors (GLIr). 313 genes were differentially expressed in Adeno-CTS-1 (Ad-CTS-1)-infected and 700 genes in uninfected 229R cells compared to matching parental cells. Responses were observed across all diseases as evidenced by decreased leukemic blast counts and/or improvements in normal hematopoiesis, and a patient with transformed CMMoL achieved a complete response. Interreceptor crosstalk and the positive feedback between different signaling. The Hh signaling pathway. By continuing you agree to the use of cookies. The heart is a sophisticated endocrine gland synthesizing the atrial natriuretic peptide prohormone which contains four peptide hormones, According to the adenoma-carcinoma sequence, colon cancer results from accumulating somatic gene mutations; environmental growth factors accelerate and augment this process.
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