Cell signaling can be defined as the cascade of pathways involving the timely delivery of the stimulus to the target by various transcription factors and signaling molecules. This pathway can become dysregulated in diabetes. NANOG is a transcription factor transcribed in pluripotent stem cells and is down-regulated upon cell differentiation. All our signaling pathways are validated at the experimental level on a large collection of tissues and cell lines on our high-throughput molecular platform, thanks to stringent and strong quality control criteria to guarantee you the best results.. We propose you a whole range of SignArrays® at the 96 or 384 plate format, compatible with most of all qPCR instruments on the market. STAT Signaling Pathway STAT signaling may hold the key to some immune deficiency research and various types of cancers. Designed to target a specific signaling pathway, our purified, reference ligands and inhibitors are a convenient and cost-effective way to validate any stable pathway cell line or assay-ready kit. Performance you can trust! PathHunter® eXpress Pathway assays are complete, ready-to-use kits, including all cells and reagents to measure pathway activation or inhibition in live cells. Cell signaling pathways can be generally categorized into groups based on area of biology. VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). The downstream signals lead to apoptosis, senescence and cell cycle arrest. Get optimal assay performance using certified chemiluminescent or fluorescent PathHunter® Detection Reagents that have been validated for use in both 96-well and 384-well microplate formats. Estrogen signaling is often dysregulated in breast cancer and osteoporosis. News: ... SPIKE - Signaling Pathway Integrated Knowledge Engine: Details: BioPAX: STCDB - Signal Transduction Classification Database: Details: STKE - Signal Transduction Knowledge Environment : Details: SBML: SuperTarget - SuperTarget: Details: Free. For Research Use Only. It results in an inflammatory and immmunological response. Nerve cells must communicate with muscle cells to create movement, immune cells must avoid destroying cells of the body, and cells must organize during the development of a baby.Some form… In combination with cell lines and fast and simple chemiluminescent detection, these signaling pathway assays will help you generate cellular pathway selectivity profiles and gain a full understanding of your compounds or biologics for receptor-proximal or -distal events without relying on complex phenotypic screens. If you know of a pathway resource that is not listed here, or have other questions or comments, please send us an e-mail. Cell signalling is part of the molecular biology system that controls and coordinates the actions of cells.
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